The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model Theoretical Biology and Medical Modelling Springer Nature Link POISON CONTROL VOLUME 7 POISONOUS EFFECTS OF PARACETAMOL OVERDOSE INTRODUCTION Paracetamol also known as acetaminophen is the mo Complete the flow chart: paracetamol overDose cannot Chegg.com Acetaminophen (Paracetamol) Toxicity A common and potentially fatal cause of acute liver failure due to toxic accumulation of the metabolite NAPQI when glutathione stores are depleted. Early recognition and timely administration A 48 hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https: bestpractice.bmj.com topics en us 1010 Paracetamol is one of the most commonly used analgesic and antipyretic drugs.