Acetaminophen & the kidney Renal Fellow Network TOXICOLOGY PARACETAMOL POISONING Paracetamol toxicity Deranged Physiology Did you know that high doses of paracetamol can be toxic to your liver? Paracetamol, also known as acetaminophen, is a commonly used painkiller that can have harmful effects on the body Acetaminophen Pathway (toxic doses), Pharmacokinetics Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect