Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect Sex differences in glutathione metabolism and acetaminophen toxicity Do You Reach for Tylenol Often? Whether it's for pain, headaches, or fever Tylenol (acetaminophen) is one of the most commonly used medications. But here's something most people don't realize Tylenol uses up the liver's stores of GLUTATHIONE. Glutathione is the body's most important ANTIOXIDANT. Tylenol and glutathione, actually explainedhere's the bullet points: * Lots of concern raised on social media re: glutathione depletion and acetaminophen use * Glutathione is used in the metabolism of acetaminophen and Acetaminophen's Role in Autism and ADHD: A Mitochondrial Perspective