Oxidative stress mediates end organ damage in a novel model of acetaminophen toxicity in Drosophila Scientific Reports TYLENOL [Acetaminophen] metabolism A lot of GLUTATHIONE is needed to deal with the Oxidative Stress generated by the CYP 450 metabolism of Tylenol. When people go to the ER for Tylenol Overdose Drug Related Pyroglutamic Acidosis: Systematic Literature Review g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Pyroglutamic acidosis Deranged Physiology