Acetaminophen Pathway (therapeutic doses), Pharmacokinetics Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Acetaminophen Toxicity: How Genetic Susceptibility Combines with Environmental Factors Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect APLB Glutathione Niacinamide Facial Toner Korea Cosmetics BN Frontiers Acetaminophen induced liver injury: Molecular mechanism and treatments from natural products