HGFMet Pathway in Regeneration and Drug Discovery Dihexa (also known as PNB 0408) is an experimental small molecule derived from angiotensin IV. It was engineered to cross the bloodbrain barrier and has shown synaptogenic effects in preclinical models. The often quoted C Met wikidoc Exploring the science behind Dihexa., Preclinical research examines its interaction with the HGF c Met pathway and associated neuroplasticity markers in laboratory and animal models. Human data Dihexa is an experimental cognitive peptide that may help the brain build stronger connections between neurons instead of just temporarily boosting neurotransmitters like many nootropics do. It works through the HGF c Met pathway, Dihexa is an experimental cognitive peptide that may help the brain build stronger connections between neurons instead of just temporarily boosting neurotransmitters like many nootropics do. It works through the HGF c Met pathway,