A 48 hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https: bestpractice.bmj.com topics en us 1010 Acetaminophen metabolism explained "simply" Since it's been blowing up my feed this week (this is not considering metabolic fates changes when pregnant) Your liver normally clears acetaminophen (Apap) safely, but in overdose, its Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect Amazon.com: Nutricology Glutathione Complex Supplement L Glutathione Complex with Vitamin C, NAC, Alpha Lipoic Acid, Tablets 90 Count : Health & Household About Acetaminophen Overdose Why patients taking enzyme Inducers and patients with anorexia nervosa experience higher risk of paracetamol toxicity?? Acetaminophen (Paracetamol) is extensively metabolized by the liver via three main hepatic pathways: glucuronidation, sulfation,