Glutathione responsive PROTAC for targeted degradation of ER in breast cancer cells ScienceDirect Cancer research is evolving every day and this one is eye opening. Scientists have discovered that cancer cells may be addicted to glutathione, a common antioxidant we usually consider healthy. Instead of just CHAC1 degradation of glutathione enhances cystinestarvationinduced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2eIF2ATF4 pathway Oncotarget ACTL6A protects gastric cancer cells against ferroptosis through induction of glutathione synthesis Nature Communications Absence of Glutathione S Transferase Theta 1 Gene is Significantly Associated with Breast Cancer Susceptibility in Pakistani Pop Identification of glutathione transferase (GST P1) inhibitors via a high throughput screening assay and implications as alternative treatment options for breast cancers PLOS One
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glutathione breast cancer Gamma-glutamyltransferase of Cancer Cells at the Crossroads of Tumor Progression, Drug Resistance and Drug Targeting