Anion Gap Acidosis Associated with Acetaminophen Annals of Internal Medicine International Journal of Oncology Metabolic activation pathway of acetaminophen. Generally, NAPQI is Download Scientific Diagram Mechanism of acetaminophen induced hepatotoxicity. High dose of Download Scientific Diagram Tylenol and glutathione, actually explainedhere's the bullet points: * Lots of concern raised on social media re: glutathione depletion and acetaminophen use * Glutathione is used in the metabolism of acetaminophen and Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: