A study published in Gastroenterology describes a new mitochondrial mediator in the hepatotoxicity induced by paracetamol. Institute of Biomedical Research of Barcelona Good ol' paracetamol: 'But an overconsumption takes its toll' Journal of Anaesthesia Practice Pharmacology 401 k Paracetamol NAPQI Glutathione COX3 Poisoning Antidote AcetylCysteine Correct Answer: B. N acetylcysteine (NAC) Why is this High Yield? Acetaminophen (Paracetamol) is widely used, making toxicity a common ER presentation. 1. Mechanism of Toxicity: Acetaminophen is metabolized in the liver. An Example of a Drug That Causes Toxicity Through the Formation of a Chemically Reactive Intermediate Mechanisms of Adverse Drug Reactions Pharmacovigilance Tylenol's Impact on Glutathione and Liver Damage