Benefits of Glutathione The progression of non alcoholic fatty liver disease (NAFLD) follows a Download Scientific Diagram Glutathione Cell Defense Integrative Therapeutics The MOST Important Fatty Liver Detox and Cleansing Antioxidant What Depletes Glutathione? How to Boost Your Glutathione Levels Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.