Full article: Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Exploring N Acetylcysteine in Psychiatry Psychiatric Times Solved The following figure shows the metabolism of the Chegg.com Old and New Analgesic Acetaminophen: Pharmacological Mechanisms Compared with Non Steroidal Anti Inflammatory Drugs Early life acetaminophen exposure, glutathione S transferase genes, and development of adolescent asthma in a high risk birth cohort Journal of Allergy and Clinical Immunology