Harvey Jay Cohen Office of the Provost Dan Purser MD E3 ligase autoinhibition by C degron mimicry maintains C degron substrate fidelity ScienceDirect If your transsulfuration pathway is off, its not just geneticsdeficiencies in B6, glutathione, glycine, serine, glutamine, or methionine can block it too. Without these, you cant convert They told you POTS was something youd just have to live with. What if thats not the full story?, Too many people are being handed prescriptions instead of answers, symptoms instead of solutions, Structural basis for C degron selectivity across KLHDCX family E3 ubiquitin ligases Nature Communications