Solved The stepwise mechanism below shows how glutathione Chegg.com NAPQI Alchetron, The Free Social Encyclopedia TYLENOL [Acetaminophen] metabolism A lot of GLUTATHIONE is needed to deal with the Oxidative Stress generated by the CYP 450 metabolism of Tylenol. When people go to the ER for Tylenol Overdose Problem 2: N acetyl para benzoquinone (NAPQI) is an oxidized Acute acetaminophen paracetamol toxicity Did you know that high doses of paracetamol can be toxic to your liver? Paracetamol, also known as acetaminophen, is a commonly used painkiller that can have harmful effects on the body