Mucosal melanocytic macules Simple cryosurgical treatment of the oral melanotic macule Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics Definition of melanocytic macules associated with Peutz Jeghers syndrome NCI Dictionary of Genetics Terms NCI Labial melanotic macule In the process of removing a Labial Melanotic Macule. A Labial Melanotic Macule is a well defined, oval, brown to black, flat patch on the central third of the lower lip, as seen Melanotic macules of the tongue in a newborn Journal of the American Academy of Dermatology