Application of glutathione depletion in cancer therapy: Enhanced ROS based therapy, ferroptosis, and chemotherapy ScienceDirect Lglutathione (GSH) is a tripeptide made of three amino acids (glutamate, cysteine and glycine) and is the body's main intracellular antioxidant. It neutralizes harmful oxygenbased molecules, protects proteins and cellular machinery from Glutathione Depletion and Stalwart Anticancer Activity of Metallotherapeutics Inducing Programmed Cell Death: Opening a New Window for Cancer Therapy ACS Omega Glutathione responsive nanomedicine leverages tumor redox imbalance for targeted cancer theranostics Discover Oncology Springer Nature Link JCI Dual targeting of the thioredoxin and glutathione systems in cancer and HIV Frontiers Glutamine's double edged sword: fueling tumor growth and offering therapeutic hope