PDF] Evidence that Increased Acetaminophen use in Genetically Vulnerable Children Appears to be a Major Cause of the Epidemics of Autism, Attention Deficit with Hyperactivity, and Asthma Semantic Scholar Full article: Metabolic phenotyping applied to pre clinical and clinical studies of acetaminophen metabolism and hepatotoxicity Illustration of the effects of acetaminophen on glutathione, Download Scientific Diagram Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Could Tylenol be making your child's health worse? Acetaminophen is widely used for pain and fever relief, but research suggests it depletes glutathione, a powerful antioxidant essential for immune function, Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.