Parents ask me this all the time: Motrin or Tylenol for fever? Here's my pediatric naturopathic perspective: Motrin treats inflammation, which often drives fever It lasts longer, so fewer doses TYLENOL [Acetaminophen] metabolism A lot of GLUTATHIONE is needed to deal with the Oxidative Stress generated by the CYP 450 metabolism of Tylenol. When people go to the ER for Tylenol Overdose Exposure to acetaminophen and all its metabolites upon 10, 15, and 20 mg kg intravenous acetaminophen in very preterm infants Pediatric Research Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health TYLENOL [Acetaminophen APAP]why it may cause harm Tylenol should likely be avoided in excess by genetically vulnerable children. GENETICALLY VULNERABLE likely meanschildren with limited supplies of GLUTATHIONE. The problem with TYLENOL