Acne and Vitamin B12 10 Skin Signs You're Low on B12 (Most People Miss These!) YouTube What Happens If You Inject B12 Wrong: 6 Red Flags Breakouts from Vitamin B12 are some of the most common I see, even in longtime clients who are using excellent skin products and otherwise have their acne under control. , B12 causes inflamed acne and Vitamin B12 supplements can trigger an acne like eruption, as can vitamin B6 & biotin supplements. In contrast to acne, there are no comedones. Once the supplements are stopped, the breakouts clear in Acne and Vitamin B12