Oral Melanotic Macule: Symptoms and Treatment Skinsight This lovely patient was thrilled with her beautiful result after laser treatment of oral melanotic macules. I share this case to educate: laser treatment requires accurate diagnosis, an understanding Labial Melanotic Macule Diagnosed by Dermoscopy Dermoscopic features of labial melanotic macules in diverse skin types Labial Macules: Dark Spots on the Lip Dermatology Advisor Brown spots, especially on the lips, can be alarming to some. In some instances it can indicate rare oral mucosal melanoma, however in this case it was a non cancerous labial melanotic macule.