The Implication of a Polymorphism in the Methylenetetrahydrofolate Reductase Gene in Homocysteine Metabolism and Related Civilisation Diseases Glutathione: Master Antioxidant, Reducing Oxidative Stress, and Detoxification Is Tap Water Safe? Its Effect on MTHFR and How to Protect Yourself Seeking Health methylation B complex+ methylated B vitamins for MTHFR gene variant* What is a MTHFR gene mutation? Methyl Life Supplements The detox gene (MTHFR) is rendered inactive when your diet is high in meat. Our diet should be 80% plant based or higher.