Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Acetaminophen metabolism PDF) Randomized controlled trial of oral glutathione supplementation on body stores of glutathione One dose of Tylenol does not ruin your child's health. The body is smart and resilient. It knows how to detox and rebalance. Our job is simply to support it. When acetaminophen Tylenol's Impact on Glutathione and Liver Damage Liposomal Glutathione 200mg, Wellgard Optiglut Dominica Ubuy