Tylenol Glutathione Kizer Wellness LLC Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Figure 1 from Acetaminophen toxicity and 5 oxoproline (pyroglutamic acid): a tale of two cycles, one an ATP depleting futile cycle and the other a useful cycle. Semantic Scholar What Is Acetaminophen? Definition, Uses, Side Effects, and Risks Olympic Behavioral Health Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine Electrochemical evidences in oxidation of acetaminophen in the presence of glutathione and N acetylcysteine Chemical Communications (RSC Publishing)