Clinically relevant therapeutic approaches against acetaminophen hepatotoxicity and acute liver failure ScienceDirect 54 Anesthesia Key Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Since everyone is talking about Tylenol let's actually talk about Tylenol. No, it doesn't cause autism But here's what it can do: Deplete glutathione: one of your body's most Should You stop Taking Tylenol (Acetaminophen, Paracetamol) What Is Acetaminophen? Definition, Uses, Side Effects, and Risks Olympic Behavioral Health