Tylenol's Impact on Glutathione and Liver Damage Mechanism of paracetamol toxicity NUS Faculty of Science NUS Faculty of Science Paracetamol Induced Hepatotoxicity , Overdose NAPQI formation Glutathione depletion Liver cell necrosis. Early N acetylcysteine (NAC) can save the liver., #Pharmacology #mbbs #Hepatotoxicity Paracetamol toxicity Deranged Physiology Haggling with HAGMA: A Common Medication with an Uncommon Differential Renal Fellow Network Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.