Treatment of labial melanotic macules on the lip. These are benign spots that appear on the lips for no apparent reason. The causes are mostly genetic, but similar spots can appear in smokers, after Dark pigmentation in the oral cavity Clinical Advisor Oral Melanotic Macule: Symptoms and Treatment Skinsight Pigmented Lesions of the Oral Cavity Oral and Maxillofacial Surgery Clinics Removal of lip pigmentation with our Alma Q laser. Such lip spots (aka labial melanotic macules) appear for no apparent reason. Similar spots can appear due to smoking, sun damage, drug reactions, Citalopram Induced Oral Melanotic Macules in a Female Patient and a Review of the Literature Cureus