Are Glutathione Injections Considered A Safe Treatment? Knowledge Bloom Tech Glutathione as a skin whitening agent: Facts, myths, evidence and controversies Indian Journal of Dermatology, Venereology and Leprology TYLENOL [Aetaminophen] metabolism Cyp 3A4 and 2E1: CYP3A4 is the major Cytochrome P 450 [Cyp] enzyme that catalyzes acetaminophen oxidation into NAPQI in human Phase I liver detox. The other Cyp enzyme Glutathione Injection For Skin Whitening: Benefits, Cost, Side Effects Glutathione: Master Antioxidant, Reducing Oxidative Stress, and Detoxification Problem 2: N acetyl para benzoquinone (NAPQI) is an oxidized metabolite of acetaminophen formed in the liver. NAPQI is converted into an acetaminophen glutathione conjugate, a non toxic metabolite