What Caused These Multiple Hyperpigmented Macules of the Mouth? Melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight in single basal melanocytes; NO nests. More info like this in Pigmented Lesions of the Oral Cavity Oral and Maxillofacial Surgery Clinics Labial melanotic macule color 43 Differential Diagnosis of Pigmented Lesions in the Oral Mucosa: A Clinical Based Overview and Narrative Review
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macule melanotic ORAL MELANOTIC MACULE (OMM) (Also called focal melanosis / labial melanotic macule) → A benign, localized, flat pigmented lesion of the oral mucosa → Caused by a focal increase in melanin production