Early life acetaminophen exposure, glutathione S transferase genes, and development of adolescent asthma in a high risk birth cohort Journal of Allergy and Clinical Immunology Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Glutathione IV Liver Detox for Rapid Liver Repair and Cleansing A Practical Approach to Avoiding Drug Nutrient Depletions NBI Sex differences in glutathione metabolism and acetaminophen toxicity Jenny McCarthy's Glutathione and Tylenol Claims: Medical Toxicologist Weighs In MedPage Today