3 Glutathione Rescue Normally, glutathione binds NAPQI and converts it into non toxic byproducts (cysteine + mercapturic acid) that are excreted. Example: Glutathione is your liver's safety net against toxins. An Example of a Drug That Causes Toxicity Through the Formation of a Chemically Reactive Intermediate Mechanisms of Adverse Drug Reactions Pharmacovigilance Clinical and Experimental Pediatrics Acetaminophen (Paracetamol) Toxicity A common and potentially fatal cause of acute liver failure due to toxic accumulation of the metabolite NAPQI when glutathione stores are depleted. Early recognition and timely administration Site of Reactivity Models Predict Molecular Reactivity of Diverse Chemicals with Glutathione Chemical Research in Toxicology NAPQI (N Acetyl 4 benzoquinone Imine) Acetaminophen Metabolite MedChemExpress