G6PD Deficiency Glucose 6 phosphate dehydrogenase deficiency X linked recessive disorder Leads to low NADPH, impairing glutathione regeneration RBCs are vulnerable to oxidative damage Pathophysiology: In G6PD deficiency: No Diabetes causes inhibition of glucose 6 phosphate dehydrogenase via activation of PKA, which contributes to oxidative stress in rat kidney cortex American Journal of Physiology Renal Physiology American Physiological Society Frontiers The global role of G6PD in infection and immunity Frontiers Recent findings in the regulation of G6PD and its role in diseases G6pd glucose6phosphate dehydrogenase pathway vector illustration graphic Premium Vector Glucose 6 phosphatase dehydrogenase (G6PD) and neurodegenerative disorders: Mapping diagnostic and therapeutic opportunities ScienceDirect