Fatty Acid Metabolism Concise Medical Knowledge Role of L carnitine in the transportation of long chain fatty acid across the mitochondria membrane. Short Note On Carnitine Shuttle: Fatty acids are oxidized in mitochondria, and synthesized in the cytoplasm. Long chain fatty acids must form an active intermediate, fatty acyl CoA, before being oxidized inside mitochondria. Catherine Critical Role of Mitochondrial Fatty Acid Metabolism in Normal Cell Function and Pathological Conditions Carnitine, Acylcarnitines and Beta Oxidation Translating the basic knowledge of mitochondrial functions to metabolic therapy: role of L carnitine Translational Research