Acetaminophen and hepatotoxicity. Acetaminophen (paracetamol) is Download Scientific Diagram Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Combination of Paracetamol and the Glutathione Depleting Agent Buthionine Sulfoximine Show Differential Effect on Liver Cancer Cells and Normal Hepatocytes Frontiers Commentary: Paracetamol Induced Glutathione Consumption: Is There a Link With Severe COVID 19 Illness? Glutathione Depletion in Mitochondrial Diseases Glutathione Reporter