What Caused These Multiple Hyperpigmented Macules of the Mouth? Labial Lentigo (labial melanotic macule) Cancer Therapy Advisor In the process of removing a Labial Melanotic Macule. A Labial Melanotic Macule is a well defined, oval, brown to black, flat patch on the central third of the lower lip, as seen Figure 1 from Oral melanotic macule a case report. Semantic Scholar Mucosal melanocytic macules Labial Lentigo (labial melanotic macule) Cancer Therapy Advisor