PARACETAMOL DEPLETES GLUTATHIONE Natural Healing Centre The Truth About Why Most Glutathione Supplements Don't Work! Synergy Institute Acupuncture & Chiropractic Glutathione, Tylenol, and Vaccines: What Parents Need to Know Lotus Homeopathy, Inc. Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Can Tylenol (acetaminophen) deplete glutathione levels in the body? Oxidative stress mediates end organ damage in a novel model of acetaminophen toxicity in Drosophila Scientific Reports