Oral Melanotic Macule MEDizzy Melanotan II 10mg Base Peptides Australia Melanotan II 10mg Pura Peptides Melanotan II Results (With Before And After Pictures) The Tanning Drug What Caused These Multiple Hyperpigmented Macules of the Mouth? Brown spots, especially on the lips, can be alarming to some. In some instances it can indicate rare oral mucosal melanoma, however in this case it was a non cancerous labial melanotic macule.