Can Tylenol (acetaminophen) deplete glutathione levels in the body? Could Tylenol be making your child's health worse? Acetaminophen is widely used for pain and fever relief, but research suggests it depletes glutathione, a powerful antioxidant essential for immune function, Glutathione: A powerful anti oxidant The New School of Nutritional Medicine Tylenol depletes glutathione your liver's most important protective antioxidant. Every dose chips away at it. So instead of taking lower doses every 46 hours, I recommend spacing to 1000mg every 8 hours. Slow Down Ageing: The Power of Glutathione Glutathione: Master Antioxidant, Reducing Oxidative Stress, and Detoxification