For 20 years, it seemed "obvious" that NSAIDs blunt training adaptation. Trappe 2002 showed ibuprofen suppressed muscle protein synthesis 24 hours after exercise. Mikkelsen 2009 showed a local NSAID infusion blocked satellite Alanine and glutathione targeting of dopamine or ibuprofen coupled polypeptide nanocarriers increases both crossing and protective effects on a bloodbrain barrier model Fluids and Barriers of the CNS Springer Nature Link Pharmacist Trick for Tylenol and ibuprofen! #tylenol #ibuprofen #philsmypharmacist #pharmacyhack Gender specific changes in energy metabolism and protein degradation as major pathways affected in livers of mice treated with ibuprofen Scientific Reports Psychopharmacology Debates: Tylenol or NSAIDs? Old and New Analgesic Acetaminophen: Pharmacological Mechanisms Compared with Non Steroidal Anti Inflammatory Drugs