The Metabolism of Acetaminophen and the Synthesis of Glutathione Download Scientific Diagram Here's how to make Tylenol work way better Dose it correctly: 1,000 mg at a time, spaced every 8 hours. Smaller doses don't control pain as well. Take it Why you should avoid REGULAR acetaminophen use for babies and pregnancy 3 Little Plums Acetaminophen Use During Pregnancy and Autism Risk Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Tylenol And Alcohol: Dangers, Safe Alternatives & Treatment