Some alternatives to consider before jumping to Tylenol! I want to emphasize that I think the fear surrounding Tylenol can be a little unnecessary and intense. I do believe there are times Acetaminophen Toxicity: How Genetic Susceptibility Combines with Environmental Factors Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Tylenol's Impact on Glutathione and Liver Damage Welcome to OPITAC Glutathione MCL's Glutathione Japanese Skin Care Premium Brands for Radiant Skin