NSAIDs Depletes Glutathione Essential Formulas Depletion of hepatic glutathione and selective protein oxidation and inhibition of lipogenesis Glutathione Depletion: The Silent Driver of Aging Calibrate Hydration Top Glutathione Alternatives: Ways to Boost Antioxidants Xandro Lab Glutathione, often dubbed the master antioxidant plays a crucial role in detoxification, immune function, and protecting our cells from oxidative stress. Here are some signs that your levels might be low: Persistent Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.