Pathology Outlines Melanotic macule A Rare Case of Oral Mucosal Pigmentation: Differential Diagnosis and Case Presentation JCDA Brown spots, especially on the lips, can be alarming to some. In some instances it can indicate rare oral mucosal melanoma, however in this case it was a non cancerous labial melanotic macule. ORAL MELANOTIC MACULE (OMM) (Also called focal melanosis labial melanotic macule) A benign, localized, flat pigmented lesion of the oral mucosa Caused by a focal increase in melanin production AD :: Annals of Dermatology Intramucosal melanocytic nevi CCIDE Dove Medical Press