Pigmented Lesions of the Oral Mucosa Pocket Dentistry Pigmented Lesions of the Oral Mucosa: Clinical Presentation, Histology, and Recommendations for Management Melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight in single basal melanocytes; NO nests. More info like this in Multifocal pigmented lesions in the maxilla Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Transformation of a benign oral pigmentation to primary oral melanoma Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics Disorders of Pigmentation of the Nails and Mucous Membranes Springer Nature Link