Is melanotan II (afamelanotide) safe to use for skin darkening? What is Melanotan II the drug that the TGA urges consumers to avoid? Melanotan 2 Reviews, Clinical Trials, and Safety Melanotan II A Sun Kissed Look, and a Confident You. Your body already makes a hormone that tells your skin to tan. Melanotan 2 is a synthetic peptide engineered to mimic that hormone but in a version that's more potent and No, you don't need the 'Barbie drug' to tan, whatever TikTok says. Here's why melanotan II is so risky