Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Heres why you should avoid Tylenol , First of all, it is full of colorful dyes, sugars, and additives., But the main reason is it depletes glutathione., Glutathione is one of the most Some alternatives to consider before jumping to Tylenol! I want to emphasize that I think the fear surrounding Tylenol can be a little unnecessary and intense. I do believe there are times Tylenol and Glutathione: Myths Debunked Understanding the Impact of Acetaminophen: Tylenol and Glutathione in Autism Parents ask me this all the time: Motrin or Tylenol for fever? Here's my pediatric naturopathic perspective: Motrin treats inflammation, which often drives fever It lasts longer, so fewer doses