Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect Frontiers Pharmacogenomics of acetaminophen in pediatric populations: a moving target Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Acetaminophen causes neurodevelopmental injury in susceptible babies and children: no valid rationale for controversy Exploring N Acetylcysteine in Psychiatry Psychiatric Times Researchers are studying a possible link between acetaminophen (Tylenol) use during pregnancy and higher autism or ADHD risk. It may lower glutathione, an important antioxidant for brain development.