Acetaminophen toxicity EMCrit Project Tylenol analogy for SBPSD members to consider Sex differences in glutathione metabolism and acetaminophen toxicity Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Glutathione, Tylenol & Your Health: What You Should Know Metabolism of acetaminophen (paracetamol) in plantstwo independent pathways result in the formation of a glutathione and a glucose conjugate Environmental Science and Pollution Research Springer Nature Link