Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Is Tylenol Bad? 5 Dangers for Children & Adults Done With Diligence When Good Drugs Go Bad: Acetaminophen Toxicity tl;dr pharmacy Tylenol And Glutathione Invigor Medical Frontiers Paracetamol Induced Glutathione Consumption: Is There a Link With Severe COVID 19 Illness?