Pigmented lesions of the oral mucosa and perioral tissues: a flow chart for the diagnosis and some recommendations for the management ScienceDirect Definition of melanocytic macules associated with Peutz Jeghers syndrome NCI Dictionary of Genetics Terms NCI Dark Spot on Lip: Harmless or Serious? What to Check First La Bouche Parfaite Labial Lentigo (labial melanotic macule) Cancer Therapy Advisor Melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight in single basal melanocytes; NO nests. More info like this in Treatment of labial melanotic macules on the lip. These are benign spots that appear on the lips for no apparent reason. The causes are mostly genetic, but similar spots can appear in smokers, after